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 Please read this guidance before applying  

  **This application form is for Stevenage and Ware February 2019 A-Level (or equivalent) GSK Work Experience ONLY**

Placement Dates:
Stevenage 18-22 Feb 2019
Ware 18-21 Feb 2019

(if you are a GCSE (or equivalent) student – please keep an eye on the website for information on programmes relevant to you)

--Please fully read this page before applying--

**Applications close 12am 16th November**

Application Advice and Tips:

- Type/copy your answers in a Word Document so that you can refer back, or if you lose your work as you are completing the application form
- We are looking for students who have a genuine interest in GSK and the work we do - make sure this comes across in your answers
- We also require a teacher's reference as part of your application - it will not be considered until we receive this - please ask your teacher to complete a separate survey

You can read further information which explains what personal information we collect, how we obtain the information, how we use your personal information and on what basis, your rights to opt out, review, update or remove your information (and have your data withdrawn from our database), and who to contact should you wish to exercise such rights or if you have any queries here:

By continuing to complete this survey you are agreeing that you understand these conditions.

Programme Information:
Placements are for Year 12 and Year 13 students only. All students will have the opportunity to gain an Industrial cadet award (Silver) on successful completion of work experience placement.

There are opportunities in:

- Biology, Bio-chemistry & Molecular Biology (Lab + non-lab placement)
- Chemistry - Analytical, Physical & Synthetic (Lab + non-lab placement)
- Working with Animals (IVSD – In Vivo Science & Delivery - Lab + non-lab)
- Information Technology and Computing (R&D Tech - non-lab placement)
- Quantitative Sciences & Clinical Development (non-lab placement for those with a strong interest in maths/modelling/statistics and experimental design)
- Engineering (pharma supply chain, office based placement)

Biology, Molecular Biology, Bio-chemistry & Bio-analysis (STEVENAGE AND WARE)

The link between genes and disease; the biology of disease and investigating biological activity of new compounds: An aim of the early research phase is to track down genes which contribute to the development of diseases. This process enables us to understand the mechanisms by which these illnesses occur and help us identify new drug targets. Examples include inflammatory disease and respiratory illnesses such as asthma. Scientists use the techniques of molecular biology, cell biology, biochemistry, enzymology, haematology and pharmacology to identify new pharmaceutical targets in such diseases and to see how new chemical compounds interact with enzymes or receptors. The latest robotics, automation and analysis play a key role in many aspects of this work. These placements will give an insight into how a modern laboratory uses a combination of biology techniques (many involving sophisticated instruments such as DNA sequencers) and computer systems for data analysis to achieve our objectives.

Screening of compounds in cellular and biochemical assays
In the early stages of drug discovery commonly small drug-like molecules are identified from a large (~1.5million) chemical library, akin to discovering a needle in a haystack. Vast efforts are then required over several years to turn such early stage molecules into prospective drugs that can be tested in clinical trials, and a key component of such efforts are a number of biological assays in which molecules can be tested to determine how chemical changes affect activity. Scientists use the skills of cell biology, biochemistry and pharmacology, together with state of the art equipment, to enable detailed comparisons of different drug-like molecules to be compared, which ultimately enables the selection of the final drug molecule for clinical trials. Placements will gain an insight into how these activities underpin modern drug discovery.

The action of enzymes on potential new drugs:
Drug metabolism studies are crucial to the development of a new drug to answer the key questions of "how much do you take" and "how often do you take it". Some work will involve analysing biological fluids from animal studies using sophisticated chromatographic or spectroscopic techniques. Other projects may involve the action of isolated enzymes on specific substrates.

Chemistry - Analytical, Physical & Synthetic (STEVENAGE AND WARE)

Doing chemistry to make the drugs of the future: Students will be working with our Synthetic Chemists, carrying out organic chemical reactions, isolating and purifying products and characterizing them using a variety of spectroscopic and chromatographic techniques. The students will work as part of the team and carry out reactions themselves under supervision. There may be opportunities to use automated robotics for carrying out some chemical reactions.

Characterising new compounds and structure- based drug design: Analysts work alongside Chemists, Pharmacists and Biologists. A wide range of analytical techniques are used to determine the identity and quality of a new chemical or drug substance. These include High Performance Liquid Chromatography (HPLC), Gas-Liquid Chromatography (GLC), Thin-Layer Chromatography (TLC), Nuclear Magnetic Resonance spectroscopy (NMR), Mass Spectrometry (MS) and other specialist methods such as protein crystallography and computational chemistry. Physical chemists determine fundamental properties of compounds such as solubility, particle/crystal size and acid/base strength. Students will use state-of-the-art equipment and computer systems.

Working with Laboratory Animals (STEVENAGE AND WARE)

The care and welfare of animals and their use in medicines research. Come and learn how medicines affect the body and how the body affects medicines: You will be working with laboratory animal scientists and technicians to assist with the many tasks covering care, welfare, socialisation and use of animals. We have rats, mice, mini pigs and at Stevenage and they each have different welfare needs and are used for researching many different types of medicines. You will able to assist on study work, however there are some limitations as to what students can actually do since all work is covered by the 1986 Government regulations on the use of animals in research. Nevertheless, there will be opportunity to observe procedures being carried out and get involved in checking the animals for clinical signs and assisting with processing of samples. These are very 'hands on' placements and are ideal for anyone who might be interested in researching new medicines, or if you are considering a career as an animal scientist/technician, vet, vet nurse or in any part of animal care industry. We provide a full itinerary visiting a variety of areas within IVSD (In Vivo Science & Delivery) as well as other disciplines within the department.
At Ware, students will spend ~50% of their time on the animal placement route touring the animal units, meeting with Pathologists/Vets and 50% of their time on the ‘biology’ placement route.

IT and Computing (Stevenage ONLY)

Developing and using computer systems for modeling studies to support R&D and analyse data: The basis of the modern pharmaceutical industry is about information and data management. This may involve project web sites; new data handling systems for analysing thousands of results that are generated by biological tests carried out by robots; or tracking compounds generated in our automated chemical synthesis programmes. The use of searching tools also allows us to gather information for setting up new projects or understand research that is going on outside the company. Powerful computer systems are used to create virtual models of chemical structures and how they interact with biological systems.

Quantitative Sciences and Clinical Development (Stevenage ONLY)

After researchers test investigational new therapies in the laboratory, promising treatments will then be studied in a series of clinical trials in patients or volunteers. These trials are designed to answer questions around the treatments effectiveness and safety. In designing a clinical trial there are many features to consider, e.g. how many patients are needed, what type of patient is needed, what is to be measured and what data to capture, what dose of the treatment, how long to treat the patient for etc. During the work experience week, students will be asked to work as a team to research, design, execute, analyse and report a mock clinical trial, using caffeine as a test medicine. The clinical trial will aim to formally test whether caffeine improves concentration and dexterity.

The team will write a clinical trial protocol, present their protocol to a mock governance board to obtain approval, run the trial recruiting volunteers from the site, analyse the data and present a summary of their conclusions. The week will give insight into the many fascinations of clinical development, and an opportunity for students to use their knowledge across a range of different subjects – e.g. human biology, maths, IT, and project management skills will be needed alongside good team work, reporting writing and presentation skills.

Engineering (Ware ONLY)

Engineering in the pharmaceutical supply chain: Engineering is a critical part of GSK, ensuring that products are safely manufactured and supplied to patients across the world. During the placement you will have the opportunity to learn about the various engineering roles that use mechanical, electrical, automation, and processing skills. Carrying out routine maintenance, diagnosing and resolving breakdowns and helping to design, install and test new equipment are just some of the tasks our engineers are involved with on site. Engineers work across multiple areas including respiratory and tablet production, micronizing, labs, utilities, and office areas. As production lines evolve and new technology is introduced this is an exciting field in which to develop.

Due to the nature of GSK's business, it is not possible to carry out ‘real’ work as part of Work Experience at GSK. Our programmes consist of simulated exercises, tours and talks to provide an overview of what it’s like to work at GSK.

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